Name:  Prazosin hydrochloride 

Synonyms:  1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride; Furazosin hydrochloride

Molecular Structure:  

Molecular Formula:  C₁₉H₂₁N₅O₄.HCl; C₁₉H₂₂ClN₅O₄

Molecular Weight:  419.87

CAS Number:  19237-84-4

EINECS:  242-903-4

 

Prazosin Hydrochloride should be stable for at least two years when stored desiccated at roomtemperature and protected from the light. Prazosin Hydrochloride is slightly soluble in isotonic saline. The approximate solubility in various  solvents (mg/ml, ambient temperature) is: water (about pH 3.5), 1.4; ethanol, 0.84; methanol, 6.4;dimethylformamide, 1.3; dimethylacetamide, 1.2; chloroform, 0.041; acetone, 0.0072.3 Prazosin Hydrochloride can be dissolved in deionized water at 1 mg/ml with the application of heat (clear, colorless to very slightly  hazy solutionsresults). Prazosin hydrochloride is not soluble in DMSO.

Prazosin hydrochloride, a quinazole derivative, is the first of a new chemical class of antihypertensive compounds. Prazosin hydrochloride is a very potent and selective a1-adrenergic antagonist. Prazosin hydrochloride reduces peripheral resistance and blood pressure by vasodilation of peripheral vessels (by blockade of a1-adrenergic receptors) in arterioles and veins without increasing the heart rate or significantly impairing sympathetic functions.