Name: Tilmicosin

Synonyms: 20-Deoxo-20-(3,5-dimethyl-1-piperidinyl)desmycosin

Molecular Structure:

Molecular Formula: C₄₆H₈₀N₂O₁₃

Molecular Weight: 869.15

CAS Number: 108050-54-0

 

Tilmicosin is a macrolide antibiotic developed for veterinary use. Tilmicosin is recommended for treatment and prevention of pneumonia in cattle, sheep and pigs, associated with Pasteurella haemolytica, P. multocida, Actinobacillus pleuropneumoniae, mycoplasma species and other microorganisms found sensitive to this compound. Tilmicosin is an antibiotic medicine with great antibiotic effect and broad antibiotic spectrum. Not show resistance and cross-resistance with other antibiotic often used in clinic. Mainly used in the Pleuropneumonia and the infection caused by Pasteurellaceae, Pasteurella and mycoplasma.

Dosage & Administration: Formulations of tilmicosin include an injectable for use in cattle and sheep (30% Injection) and premix formulations for swine (4%, 10% & 20% Premix). The recommended dose of the injectable formulation in both cattle and sheep is a single subcutaneous injection of 10 mg/kg BW. Recommended dose for swine in feed is 200-400 mg/kg of feed for 10 to 21 days, equivalent to 8-20 mg/kg BW per day.

 

Specification: USP30

Item	Specification
Character	White to almost white power
Identification	The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
	IR spectra is consistent with CRS.
Related substances (On dried basis)	Individual impurity: 3.0% Max.
	Total impurities: 10.0% Max.
Water	5.0% Max.
Tilmicosin Cis-isomers	82.0 ~ 88.0%
TilmicosinTrans-isomers	12.0 ~ 18.0%
Assay (On dried basis)	Content of C46H80N2O13: 85.0% Min.

 

Packing: 10kg/drum