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Neomycin Sulphate
Name: Neomycin sulfate; Neomycin Sulphate
Synonyms: Mycifradin sulfate; O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy sulfate
Molecular Structure:
Molecular Formula: C23H46N6O13.3(H2SO4); C23H52N6O25S3
Molecular Weight: 908.87
CAS Number: 1405-10-3
EINECS Number: 215-773-1
 
 
Neomycin is an aminoglycoside antibiotic that is found in many topical medications such as creams, ointments and eyedrops.
 
Neomycin is overwhelmingly used as a topical preparation, such as Neosporin. Neomycin can also be given orally, where it is usually combined with other antibiotics. Neomycin is not absorbed from the gastrointestinal tract, and has been used as a preventative measure for hepatic encephalopathy and hypercholesterolemia. By killing bacteria in the intestinal tract, it keeps ammonia levels low and prevents hepatic encephalopathy, especially prior to GI surgery. Neomycin has also been used to treat small intestinal bacterial overgrowth. It is not given intravenously, as neomycin is extremely nephrotoxic (causes kidney damage), especially compared to other aminoglycosides. The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 0.025 mg per dose.
 
Specification: BP2003/USP29
Item
Specification
BP2003
USP29
Characteristics
White or yellowish-white powder, odorless or almost, hygroscopic
Identification
A; B; C: The positive reaction
Solubility
Very soluble in water, insoluble in acetone, chloroform, ether
Specific optical rotation
+53.5o ~ +59.0o
 
Acidity or alkalinity
5.0 ~ 7.5
5.0 ~ 7.5
Related substances
Impurity A
2% Max.
Impurity C
3 ~ 15%
Any other impurity
Not more than the area of the principal peak in the chromatogram obtained with RS(B) (5%)
Total impurities
Not more than 3 times the area of the principal peak in the chromatogram obtained with RS(B) (15%)
Disregard limit
Area of the principal peak in the chromatogram obtained with RS(C) (0.1%)
Sulphate
27.0 ~ 31.0%
Loss on drying
8% Max.
8% Max.
Assay
680 IU/mg Min.
600 ¦Ìg/mg Min.
 
Packing: 25kg/drum
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