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Florfenicol
Name: Florfenicol
Synonyms: [R-(R*, R*)]-N-[1-(Fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide; 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Molecular Structure:
Molecular Formula: C12H14Cl2FNO4S
Molecular Weight: 358.21
CAS Number: 73231-34-2 (76639-94-6)
 
 
Florfenicol is a fluorinated synthetic analog of thiamphenicol, broad-spectrum antibiotic active against many gram-negative and gram-positive bacteria isolated from domestic animals.
In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, for treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
 
Dosage: Florfenicol is to be fed at 20 to 40g (20ppm-40ppm) per ton feed.
 
 
Specification: CPV2006
Item
Specification
Character
White or almost white crystalline powder
Melting point
152 ~ 156¡æ
Specific optical rotation
¨C16o ~ ¨C19o
Identification
The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.
UV absorption Max. at 266nm.
IR spectra is consistent with CRS.
pH
4.5 ~ 6.5
Chlorides
0.02% Max.
Fluorides
4.8% Min.
Related substances
Individual impurity: 0.5% Max.
Total impurities: 2.0% Max.
Water
0.5% Max.
Residual on ignition
0.1% Max.
Heavy metals
20ppm Max.
Assay (on dried basis)
Content of C12H14Cl2FNO4S: 98.0% Min.
 
Packing: 25kg/drum
View Veterinary Item.