Name:Dimethyl fumarate

Synonyms: (E)-2-Butenedioic acid dimethyl ester

 

Molecular Structure :  

Molecular Formula :C₆H₈O₄

Molecular Weight :144.13

CAS Registry Number :624-49-7

EINECS :210-849-0

Dimethyl fumarate is an ester and an ¦Á,¦Â-unsaturated electrophilic compound, undergoing reactions typical to them. It is also a diene acceptor in the ordinary Diels-Alder reaction, where the reactivity of its vinylidenic bond is enchanced by the two electron-withdrawing ester groups. Due to the geometry of the starting ester, the Diels-Alder product will have a trans configuration.

Dimethyl fumarate is used to treat psoriasis. It is a lipophilic, highly mobile molecule in human tissue. However, as an ¦Á,¦Â-unsaturated ester, dimethyl fumarate reacts rapidly with the detoxifying agent glutathione by Michael addition. When administered orally, it does not survive long enough to be absorbed into blood.

Another use for dimethyl fumarate is mold inhibition, mostly for leather products.

Tests in mouse models have been conducted with the aim of using it as part of a specific cancer treatment.

Dimethyl fumarate has been found to be an allergic sensitizer at very low concentrations, producing extensive, pronounced eczema that is difficult to treat. Concentrations as low as 1 ppm may produce allergic reactions. There are only a handful of equally potent sensitizers

 

 

Package:Packed in hard paperbox,Lined with a polyethylene bag,N.W.20kg each,in which contens 1kg or 5kg little bags.

Storage:Keep away from light and heat. Moistureproof and water

Shelf life:.2 years from date of production