¡ãName:  Aminophylline

Synonyms: Aminophylline Anhydrous; Theophylline-ethylenediamine-addition compound (2:1); 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione cmpd. with 1,2-ethanediamine (2:1)

Molecular Structure:  

Molecular Formula:  2(C₇H₈N₄O₂).C₂H₈N₂

Molecular Weight:  420.43

CAS Number:  317-34-0

EINECS:  206-264-5

Melting point:  269-270 oC

Water solubility:  soluble

 

Aminophylline is a bronchodilator drug combination that contains theophylline and ethylenediamine in 2:1 ratio.

Aminophylline Anhydrous is more soluble in water than theophylline. Aminophylline Anhydrous is a kind of white or slightly yellowish granules or powder, having a slight ammoniacal odor and a bitter taste. Upon exposure to air, Aminophylline Anhydrous gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Its solutions are alkaline. One g dissolves in 25 mL of water to give a clear solution; 1 g dissolved in 5 mL of water crystallizes upon standing, but redissolves when a small amount of ethylenediamine is added. Aminophylline Anhydrous  is insoluble in alcohol and in ether.

Aminophylline is less potent and shorter-acting than theophylline. Its most common use is in the treatment of bronchial asthma. Causes bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion by blocking phosphodiesterase which increases tissue concentrations of cyclic adenine monophosphate (cAMP) which in turn promotes catecholamine stimulation of lipolysis, glycogenolysis, and gluconeogenesis and induces release of epinephrine from adrenal medulla cells

Aminophylline has shown some promise as a bodyfat reducer when used as a topical cream. Aminophylline is also a treatment option for anaphylactic shock.

 

Specification£º EP4.0 EDMF available

Package£º25kgs fibre drum

Use£º Bronchodilator